Basic Information
VIS ID
TVIS10017152
Fusion event
HBV-chr4 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1384
End
1479
Integrated sequence
AGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGG
Host Sequence
Chromosome
chr4
Cytoband
p11
Reference genome
GRCh37/hg19
Start
49140157/49138140 (Hg38)
End
49140246/49138229 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/1485397; hsa-mir-1243/Downstream/3574453;
Nearest TSS
ENST00000502981/Upstream/109448; ENST00000504661/Downstream/2704771;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/151349, chr4-CpG: 24/Downstream/23211
Upstream sequence
GATTTGCTCTGTTAACCCTGCTATGGGAGCTGGTGGAGGGAAGGTTGGAGGTGAGGTGATTGGCTGTGGTCTAGACCAGTTTTCAAACTAACTTCCTCAA
Downstream sequence
attccattccattccatatctttccaccaaagttgattgcatgctattccattccattccattccattccattccattccattccattccgttcctttcc
Target sequence
ttccattccattccattccattccattccattccattgcattccactggggttgattccattccattccattccattccattccattcc
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate