Basic Information
VIS ID
TVIS10017155
Fusion event
HBV-chr7 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1729
End
1773
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTA
Host Sequence
Chromosome
chr7
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
14131064/14091439 (Hg38)
End
14131168/14091543 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-339/Upstream/7024394; hsa-mir-10399/Downstream/4035677;
Nearest TSS
ENST00000635602/Upstream/100014; ENST00000412014/Downstream/177658;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/99851, chr7-CpG: 17/Downstream/2307954
Upstream sequence
ACCTCGGTTTCCGCCATCCATCTCCATGCTCCTGCCCATGCTCTAGCCCCTCCAGACCCCTGCACAGTTTGTAATGGACAGAATGGAAACACATCTTTCT
Downstream sequence
tgaggtgaccactgaacacccacatttcattgtggctttacgttctcttctaaaatgtacagcatacaaaattccagtagagagctaaaaaaactctgtt
Target sequence
tgatagatgtctatgttatatagaaatttgtaatttagctaattacgagcttgagcaactaaaagcaaaaggctacagtgtagaaatgagctccaggtagcgag
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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