Basic Information
VIS ID
TVIS10017156
Fusion event
HBV-chr9 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1114
End
1228
Integrated sequence
GGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCAT
Host Sequence
Chromosome
chr9
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
32531477/32531479 (Hg38)
End
32531600/32531602 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA9C
Nearest miRNA
hsa-mir-101-2/Upstream/3642524; hsa-let-7a-1/Downstream/577090;
Nearest TSS
ENST00000422679/Upstream/5155; ENST00000450093/Downstream/19542;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/5053, chr9-CpG: 146/Downstream/18959
Nearby gene
DDX58(-5155) ; TOPORS(+9065) ;
Nearest cancer related gene
DDX58(TSG, -5155) ; TOPORS(TSG, +9065) ;
Upstream sequence
TGCAAAGAAACTTTAGAAGTGGTATGggctgggcacggaggttcacccctgtaatcccagcattttgggaggctgaggtaggtggatcacaaggtcagga
Downstream sequence
taaagatttgagtgaaagttatacaaaaattttagggcttgttttctgtgtctactttctgaaatttctccctcaaaatgcagtcactcgggcagcccca
Target sequence
tccaagttctatattccctgtggtggtggctgaaatgtatctattgagcccttttagctttccagctattgcttacatgggctttttggaatcttccctgcacatgtacatttcagggtcagg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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