Basic Information
VIS ID
TVIS10017157
Fusion event
HBV-chr10 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
602
End
713
Integrated sequence
TATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTT
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
42534522/41705571 (Hg38)
End
42534637/41705686 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1265/Upstream/6064319; hsa-mir-107/Downstream/1291877;
Nearest TSS
ENST00000439456/Upstream/3252390; ENST00000442306/Downstream/479653;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2762465, chr10-CpG: 184/Downstream/405347
Upstream sequence
TTGGTCcattttcaaagtgggaaaatagaagtatgcaagatgaaataacttgcttgaggtcacacagtcaagtactggcaggccggggatgagaagccag
Downstream sequence
gttttaattcgaagatatttccatttctaagattggcctcaaatcccttgaaatctccacttgcaaattccacaaaaagagtgtttcaaaactgctctga
Target sequence
ccacttgcagactttacaaagacagcgtttccaaactgctctatgaaaagaaacgttaaactctgtgagttgaacgcacacatcacaaactagtttctgcgaatgattctgtgta
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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