SDS _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017160
Fusion event
HBV-SDS integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1710
End
1824
Integrated sequence
CAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT
Host Sequence
Chromosome
chr12
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
113830885/113393080 (Hg38)
End
113831008/113393203 (Hg38)
Location type
Exon
Fragile sites / regions
FRA12E ; FRA12D
Target gene
SDS
Nearest miRNA
hsa-let-7i/Upstream/101472; hsa-mir-1178/Downstream/2755357;
Nearest TSS
ENST00000382841/Upstream/18214; ENST00000547802/Downstream/10683;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/34038, chr12-CpG: 409/Downstream/69742
Upstream sequence
caatagcttaggatgcatttcaagggtaagccggttgatacctgagtgtttcccacctgaaagacaaaaccgtccgcagttttggtttgtttgtttcccc
Downstream sequence
GAGCTGACAGGCCATTGGCAGGACCTGGGAATACTGAGCCAATCAGCTCTCAGCCCTGGCTGCAGCCGCAGGTCCTGAACCAAACGTCCCGTCATCGGCC
Target sequence
GGATCACGTGGCTATAGACAGCGGCCAGGGCTGCCCCGCAGGCGGGCTCCACCAGGATCTTCTCATCATCTGCCAGAGAAGGGGCGTGACAGGGGCGTGGCCTGAGTTTCCCAGGGTGCACAG
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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