ANK3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017164
Fusion event
HBV-ANK3 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
515
End
582
Integrated sequence
ATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTT
Host Sequence
Chromosome
chr10
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
61786242/60026484 (Hg38)
End
61786325/60026567 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
ANK3
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-8088 ; hsa-mir-598-5p ; hsa-mir-216b-3p ; hsa-mir-8485 ; hsa-mir-603 ; hsa-mir-503-5p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-1265/Upstream/2721925; hsa-mir-107/Downstream/3346390;
Nearest TSS
ENST00000439456/Upstream/65571; ENST00000619719/Downstream/18236;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/119448, chr10-CpG: 60/Downstream/706460
Upstream sequence
ATAATTTCCATTGCTATTGGGATAAAGAGGAAACATTGCTATGGCCTCCCAGGTCTTTGGCAGAGGTCTGGctactgacctcccgctgccgtggccttgg
Downstream sequence
TGACAATAGTTTATTGGCCATGGAGAAAATCCTCAGTCTTGATGGAACTCCAGGATGATACCAAATGAACAGCGAGGAACATCAGGATGCCAAAAAGTCC
Target sequence
CTCAGAAGATGCCTTATTATTTTTGTGATTTATTTCTGGGCTTCTCACATATCCCTGTCATACAGCCAAACGTGAGCTGATGC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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