Basic Information
VIS ID
TVIS10017165
Fusion event
HBV-chr11 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1873
End
1975
Integrated sequence
CCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCC
Host Sequence
Chromosome
chr11
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
68982963/69215496 (Hg38)
End
68983036/69215569 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA11H ; FRA11A
Nearest miRNA
hsa-mir-10392/Upstream/132238; hsa-let-7a-2/Downstream/1068386;
Nearest TSS
ENST00000527297/Upstream/43932; ENST00000540760/Downstream/78569;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/58007, chr11-CpG: 26/Downstream/161490
Upstream sequence
catactcaaatccacttcctcctgctaccaattccCTTCAACTACCTGCCTCCCCCAACCCCTCTGAATTGCTAAGCACCACTCTTCTGGATGTCTCTAA
Downstream sequence
TTCCCAGTGCAGAGGTGCCTGGGCTATTAATAGCAGAGGAATCTGGGCTCCATCACCAGCCTTtccatccatccatccatccatccatccatccatccat
Target sequence
ATTTGTTTCAGGGTGTCTTGTTGGTTTTCCAGCTCCAACCTGGCTCAGGATCTCCTTTTGTTTTTTGGACTCA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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