ANO1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017166
Fusion event
HBV-ANO1 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
3084
End
3188
Integrated sequence
CAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr11
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
70000541/70154435 (Hg38)
End
70000581/70154475 (Hg38)
Location type
Intron
Fragile sites / regions
FRA11H ; FRA11A
Target gene
ANO1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-381-3p
Nearest miRNA
hsa-mir-10392/Upstream/1071177; hsa-let-7a-2/Downstream/129480;
Nearest TSS
ENST00000527297/Upstream/12841; ENST00000529636/Downstream/10887;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/66332, chr11-CpG: 18/Downstream/1172
Upstream sequence
ctctgtcacccaggttggaatgcagtggcgccatctcagctcactgcaacctctgcctcccgggtccaaacgactgtcatgcctcagtctcccaagtagc
Downstream sequence
tttttttttgagagggagtctcgctttgtagcccaggctggagtgcagtggcgcgatctcagctcactgcaagctctgcctcccaggttcacgccattct
Target sequence
CCTATAGCCAGGAAGGAAGTATGtcttttttttttttttt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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