Basic Information
VIS ID
TVIS10017167
Fusion event
HBV-chr16 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1158
End
1274
Integrated sequence
GGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTG
Host Sequence
Chromosome
chr16
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
25578079/25566758 (Hg38)
End
25578197/25566876 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA16E
Nearest miRNA
hsa-mir-1225/Upstream/1363527; hsa-mir-11401/Downstream/458361;
Nearest TSS
ENST00000527434/Upstream/142589; ENST00000475436/Downstream/125150;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/308351, chr16-CpG: 138/Downstream/124758
Upstream sequence
tcattcaattccattcgataatgattcccttcgagtccattcgatgattccattcgattccattcaacgatgattccactcaaatccattggatgattcc
Downstream sequence
gggattacaggcgtgagccaccgcgccgggcccaagctcctgcgtcttaattccatggccattgagtaacgcctgcactgcttgacgctcactttcagtt
Target sequence
tgccaccacacccagctaatttttgtatttttagtagagacggagttttaccatgttagccaggatggtctccatctcttgacctcgtgatccacccatgttggcctcccaaagtgct
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate