Basic Information
VIS ID
TVIS10017168
Fusion event
HBV-chr3 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
465
End
574
Integrated sequence
TTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTAC
Host Sequence
Chromosome
chr3
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
161101161/161383373 (Hg38)
End
161101202/161383414 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/978548; hsa-mir-1224/Downstream/2788057;
Nearest TSS
ENST00000440867/Upstream/10493; ENST00000602890/Downstream/43013;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/10512, chr3-CpG: 20/Downstream/2620848
Nearby gene
LOC107986150(+1747) ;
Upstream sequence
GCTGCCTGCCTGGTCCCATCTTAATCCACCCACTGCCCTTCATGGCCTGGAACTCGGTTCTCCCTCCCGGTAGAGTCAGCAGTGGCTTCCCCTCCCAGTC
Downstream sequence
tgtggatgtaacatttgtggttccactatatttaaagcattctagaggtccattaaatttgtaattttgctgagacacaagcttgaattctgaatttgat
Target sequence
ATCATTAAGTGATGAAGGCCTTAAaataaactcttggcata
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate