Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017171
Fusion event
HBV-TERT integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Start
2435
End
2542
Integrated sequence
TCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTT
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
Start
End
1296131/1296016 (Hg38)
Location type
Promoter
Target gene
miRNAs that regulate target gene
hsa-mir-138-5p ; hsa-mir-498 ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-512-5p ; hsa-mir-1207-5p ; hsa-mir-1266-5p ; hsa-mir-1182 ; hsa-mir-181a-5p ; hsa-mir-6776-3p ; hsa-mir-197-3p ; hsa-mir-6740-3p ; hsa-mir-6760-3p ; hsa-mir-532-5p ; hsa-mir-3064-5p ; hsa-mir-422a ; hsa-mir-346 ; hsa-mir-1226-3p ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-143-3p ; hsa-mir-3161 ; hsa-mir-3605-5p ; hsa-mir-3620-3p ; hsa-mir-3682-3p ; hsa-mir-4323 ; hsa-mir-4712-3p ; hsa-mir-4733-3p ; hsa-mir-4758-3p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-7112-3p
Nearest miRNA
hsa-mir-4635/Upstream/232916; hsa-mir-10397/Downstream/13294;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/35, chr5-CpG: 18/Downstream/38946
Nearest cancer related gene
TERT(OG, No orient, 0)
Upstream sequence
CCACCAGCGCGCGGAAAGCCGCCGGGTCCCCGCGCTGCACCAGCCGCCAGCCCTGGGGCCCCAGGCGCCGCACGAACGTGGCCAGCGGCAGCACCTCGCG
Downstream sequence
CCAGCCCAGCAGTAGAAGCCACACGGCCACTGGTCCCCTCCAGACCTGGGGCCCCGGCACAACCGCAGGACAGCTGAGGACTTCCCAGGAATCCAGACTC
Target sequence
CCGGCACTCTGTCTGGCAGATGAGGCCAACATCTGGTCACATCCCGCCCGCACAGGGTGGAGGGCAACCTCGGGGTCCAGGCACCTGGCTCCAAGCCTCGGACTGCAGAGCTAGGAGGCCCGACTT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.