CDK14 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017173
Fusion event
HBV-CDK14 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1828
End
1939
Integrated sequence
ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGT
Host Sequence
Chromosome
chr7
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
90318864/90689550 (Hg38)
End
90318984/90689670 (Hg38)
Location type
Intron
Target gene
CDK14
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-376c-3p ; hsa-mir-493-5p ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-6785-5p ; hsa-mir-6883-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-4533 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-6783-5p ; hsa-mir-4419a ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6873-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-4428
Nearest miRNA
hsa-mir-10525/Upstream/14774281; hsa-mir-10399/Downstream/1514345;
Nearest TSS
ENST00000635602/Upstream/92197; ENST00000496279/Downstream/19581;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/92500, chr7-CpG: 255/Downstream/574608
Nearest cancer related gene
CDK14(OG, No orient, 0)
Upstream sequence
tgaatcttgtgacctctggctacatgactcctgagccataatttctagtctcatggctaatttgttagttttacaaaggtggtttcaaaggaggctgtag
Downstream sequence
GACTGTTGTGAACAGACTGCTTTTATATTTAATGTTTATAAAATGAGTTTCCATAATCCTATATCTTTCCATAATTCCAGGGAATTTTGACCTCAAAATA
Target sequence
AAAGACCGAAGGCATTTTTACAATTAGATCTTCTCATACTACCCCAGGGAAAACCATTAGCCCAGACTAGTTTAGCTGCTGACTAGAAATTTGTTCCTTGGGGAAGGGTAAGAAATACAT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate