Fusion event
HBV-KLRG2 integration
Detection method
Capture-NGS platform
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
CTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGG
End
139163872/139479126 (Hg38)
Nearest miRNA
hsa-mir-10399/Upstream/434873; hsa-mir-11400/Downstream/2995401;
Upstream sequence
GCAGTTTCTGCTGGACATCAGGGTGAGTGGCCAGTTCATACATAATGAAGGAGAGAACACTGCTCGTGGTTTCATAGCCAGCAAAAATAAAGATAATTGA
Downstream sequence
ggctggagtgcagtggagtgatctcggctcactgcaacctctgcctcccaggttcaagcaattctcctgcctcagcctcctaaatagctgggattacagg
Target sequence
cctggccaacatcgtgagaccctgtcccttaaaaaaaaattatttttatttttatttatttatttattttgagacggagccttgctctgttgccca
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.