CDKN2A _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017176
Fusion event
HBV-CDKN2A integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1162
End
1273
Integrated sequence
ACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACT
Host Sequence
Chromosome
chr9
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
21993692/21993693 (Hg38)
End
21993807/21993808 (Hg38)
Location type
Intron
Fragile sites / regions
FRA9C
Target gene
CDKN2A
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-let-7g-5p ; hsa-mir-125b-5p ; hsa-mir-492 ; hsa-mir-10b-5p ; hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-34a-5p ; hsa-mir-192-5p ; hsa-mir-16-5p ; hsa-mir-455-3p ; hsa-mir-423-5p ; hsa-mir-296-3p ; hsa-mir-615-3p ; hsa-mir-320a
Nearest miRNA
hsa-mir-101-2/Upstream/481508; hsa-let-7a-1/Downstream/6869818;
Nearest TSS
ENST00000422679/Upstream/18595; ENST00000645313/Downstream/603;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/3584, chr9-CpG: 156/Downstream/294
Nearest cancer related gene
CDKN2A(TSG, No orient, 0)
Upstream sequence
TTGCTCCTATCTACTTTCTTCTCTAGAATCCACTGGTAAGCCACATCTAATGAAGAGAATATTTAACCATAAAATCTTAAGGAAAAGTTGTATGATTTAA
Downstream sequence
gtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtCTTAGTCATTCCCACCCAGGATATTCGGGACTCACTGACTTCTGAGGTGGGTTTAGAAGCTC
Target sequence
CGCCGGGAGGCTGGGGAGAAAAAAGGCCGCCTCCAGAAAACTTAGATGGTTAGCAATAATTCTCCCCAAGGAGAAAGAAAGTGTGCTTGAAATACACCTTTCCTACtgtgtgtgt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate