Basic Information
VIS ID
TVIS10017177
Fusion event
HBV-chr9 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1180
End
1294
Integrated sequence
AGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGT
Host Sequence
Chromosome
chr9
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
25037310/25037312 (Hg38)
End
25037433/25037435 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA9C
Nearest miRNA
hsa-mir-101-2/Upstream/3525127; hsa-let-7a-1/Downstream/3826191;
Nearest TSS
ENST00000422679/Upstream/491314; ENST00000627303/Downstream/641005;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/1185788, chr9-CpG: 111/Downstream/640061
Upstream sequence
tgcgggttatatttatagccagagaaaaaaagtgacatacagaaaacagaagtgaggtatagaggtggctggattggttacagacctggttacagcccgg
Downstream sequence
tttcaacatgtgatttgagtgggaacagagatccaaaccatatcatcatcattagtggaaaggaacaggtagagataagcctatgccatcttgtctgggc
Target sequence
aaccagatcacgtgagaactctatcacaagacagcactagggtgatggtgctaaaccatcagaaacagccctcacgatccaatcacctacccccaggctgctcctccaacattgcagattaca
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate