Basic Information
VIS ID
TVIS10017178
Fusion event
HBV-PHF24 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1820
End
1934
Integrated sequence
ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCT
Host Sequence
Chromosome
chr9
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
34855114/34855117 (Hg38)
End
34855236/34855239 (Hg38)
Location type
Intronic
Target gene
PHF24
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-101-2/Upstream/1387182; hsa-let-7a-1/Downstream/752855;
Nearest TSS
ENST00000422679/Upstream/125650; ENST00000486477/Downstream/40483;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/44885, chr9-CpG: 93/Downstream/102481
Upstream sequence
ACAGAGCCCATGCCTGTGCTGTCCTCACACCCAACATGAGGACTAAGTATTGGCTTCATCATCAGTGAGATTTCCTAAGGAGAATTTCACACCGAGGTGA
Downstream sequence
gtatcttttaattggggcatttaacccatttacatttaagattaacattgttatgtgtgaatttgatcctgtcatcatgatgctagctagttattttgca
Target sequence
tttgcttggtaaaatttcccccatccttttattttgagcctatgtgtgtctttgcacattagatgggtctcttgaagacagcataccaatggggcttggctctttatccagcttgccattct
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate