Basic Information
VIS ID
TVIS10017179
Fusion event
HBV-chr9 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1660
End
1772
Integrated sequence
AGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGT
Host Sequence
Chromosome
chr9
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
42223657/40078639 (Hg38)
End
42223779/40078761 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-101-2/Upstream/3185108; hsa-let-7a-1/Downstream/850249;
Nearest TSS
ENST00000422679/Upstream/268542; ENST00000425632/Downstream/52160;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/268815, chr9-CpG: 116/Downstream/143307
Upstream sequence
TGAGTTATTACTTATCTTTGATTTGATATAGTTCTGCCCCAATTCAGCTTAGGTGCCTGAGTTTGTCCTCACTTTGTATGTTTTAGTAGTGGTTTCTCAG
Downstream sequence
GTGTTTGCAGTATGTGTAATAGAGTTAAATATATCTAAATATAGTATATCTGTACTAAGGCAATGAACATCAATTGTAGCTAATCACCCTCATTAAAGCA
Target sequence
GATATCCATGTGAGATAATTAATTCCTCTGCTATCTATTTTATTATACTTAGTTATTCATCTAAAATAAATATCTACTATAACAAGTAAAATATATAATAGTGTAGAAGACAACAAGAGTAT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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