Fusion event
HBV-DAB2IP integration
Detection method
Capture-NGS platform
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
CTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTT
End
124439548/121677269 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-let-7a-1/Upstream/1432126; hsa-mir-12126/Downstream/442813;
Nearest cancer related gene
Upstream sequence
actccagagccaagacaacccccacagacccaggctccaagctggtcccctggtctaggatgtagagcagcacttgtggacctgggtttcatgcctgccc
Downstream sequence
gcactttgggaggccaaggtgggaggatcgcttgaggccaggagtttgagaccagcttgggcaacaaaggaaacccccatctctacaattttttttaaaa
Target sequence
AGCCTCTGGAAAATAACTGGAAGCCagaagtcacagattctcatgtttgaaaaaacgtgggggctgacatagtggctgagccctgtaatccca
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.