Basic Information
VIS ID
TVIS10017181
Fusion event
HBV-chr10 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1086
End
1195
Integrated sequence
AGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCA
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
42385980/41854122 (Hg38)
End
42386086/41854228 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1265/Upstream/6212870; hsa-mir-107/Downstream/1143335;
Nearest TSS
ENST00000439456/Upstream/3400941; ENST00000442306/Downstream/331111;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2911016, chr10-CpG: 184/Downstream/256805
Upstream sequence
aaACTGCACACCTTTAGATAACTATGAGTTATAGGACCCCATGAATGGCAGGTGAAAATTTTTCCTCTAAATATATATTATTTCAGAGAAAGCCACAATG
Downstream sequence
atggaatcatcgtcgaacggaaacaaatggaatcatcatcgaatgcaaatgaaaggagtcatcatctaatggaatcgcatggaatcatcatcaaatggaa
Target sequence
tggaatggaatggaataatccatggactcgaatgcaatcatcatcgaatagaatcgaatggaatcatcgaatggactcgaatggaataatcattgaacggaatcga
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate