Basic Information
VIS ID
TVIS10017184
Fusion event
HBV-chr13 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2698
End
2809
Integrated sequence
CCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCAT
Host Sequence
Chromosome
chr13
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
66106535/65532403 (Hg38)
End
66106654/65532522 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA13B
Nearest miRNA
hsa-mir-1297/Upstream/4332523; hsa-mir-1267/Downstream/433808;
Nearest TSS
ENST00000623511/Upstream/1456392; ENST00000437777/Downstream/333652;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1687857, chr13-CpG: 92/Downstream/1697854
Upstream sequence
AAATGTAACAGTAATGTAAACATGCCAAAAATATAATAGAAGCTAAATCGTGGTAGGTGATATGATATTTCTCACTAAAATGCCACGTAGTACTTTTTTG
Downstream sequence
TTAGTACGGTCATTTCAGTTTCTTAATTAGAAGAAGCTGAGAGTTAACATTTAAAAAAGTACCATGTTACACAGCAAAGATTTTATGATTTCTCATGGAG
Target sequence
GTCTTTCTCAAAGTAATTTCCCAGTCAAGGCAGTAGCTGCTATTGTTTGTCCACTCTCCCTGTTTTATCTCCTTGGGCGTGAAATGTCACGTGGAAAAGGCATTAGCCTCCTGAGGGAC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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