Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017185
Fusion event
HBV-NTRK3 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
Start
1626
End
1736
Integrated sequence
CGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGA
Host Sequence
Chromosome
chr15
Cytoband
q25.3
Reference genome
Start
End
88526730/87983499 (Hg38)
Location type
Intron
Target gene
miRNAs that regulate target gene
hsa-mir-765 ; hsa-mir-485-3p ; hsa-mir-128-3p ; hsa-mir-9-5p ; hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-617 ; hsa-mir-345-5p ; hsa-mir-384 ; hsa-mir-330-3p ; hsa-mir-198 ; hsa-mir-625-5p ; hsa-mir-509-3p ; hsa-mir-151a-3p ; hsa-mir-185-5p ; hsa-mir-768-5p ; hsa-mir-615-3p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-1277-5p ; hsa-mir-410-3p ; hsa-mir-4776-3p ; hsa-mir-192-3p
Nearest miRNA
hsa-mir-10393/Upstream/37109; hsa-mir-1179/Downstream/624608;
Nearest CpG islands
Nearest cancer related gene
NTRK3(OG, No orient, 0)
Upstream sequence
catctgttctgctcttaatttcaagtgtaaaaagTATTACTTTCCTAATTCCGTCAAGGGGAGGGAGAATATGTATTCCTAAAGACCACAGTTCTTGTAT
Downstream sequence
ATATAAGGGAGTGCCAGTGacaggtatcacctacagttagttctttatacctcaacatccccaaaaggtggatagtattaactccactttacaagggaga
Target sequence
TGAGATGTTTTTCAACCCCATTGCAGGTAGGCATGGAATGGAGCAGGGAGCCCCGAGCAATACCCAACTATGCCAATCGTACCATCAGACATGTTGCTGATAGCCCTGGAATCCATAGATCT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.