Basic Information
VIS ID
TVIS10017186
Fusion event
HBV-chr13 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1721
End
1824
Integrated sequence
TGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT
Host Sequence
Chromosome
chr13
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
61538340/60964206 (Hg38)
End
61538387/60964253 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA13B
Nearest miRNA
hsa-mir-1297/Upstream/5789658; hsa-mir-1267/Downstream/235545;
Nearest TSS
ENST00000623511/Upstream/47164; ENST00000455977/Downstream/451269;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/566295, chr13-CpG: 36/Downstream/2847333
Upstream sequence
CCTGGACCATCTGTAGCTCATCACTTTCTTGGTCAATTATAGATGAAGAAAGTCATGAAATACTGAATAGATAATCCATCAAATACAACCAAGTGCATGA
Downstream sequence
agaaagggtttcaccatgttggccaggctggtcttgaactcctgacctcaggtgatctgcccacctcagcctcccaaagtgctgggattacaggcgtaag
Target sequence
tacaggcgcccgccaccatggccagctaatttttgtattttttgtag
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate