Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017188
Fusion event
HBV-AKAP10 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Start
755
End
854
Integrated sequence
TTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGA
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
Start
End
19811245/19907932 (Hg38)
Location type
Intron
Target gene
miRNAs that regulate target gene
hsa-mir-339-5p ; hsa-mir-331-3p ; hsa-mir-155-5p ; hsa-mir-190a-3p ; hsa-mir-5580-3p ; hsa-mir-6505-5p ; hsa-mir-106a-3p ; hsa-mir-3191-5p ; hsa-mir-5571-5p ; hsa-mir-3671 ; hsa-mir-10a-3p ; hsa-mir-367-3p ; hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-363-3p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-548aw ; hsa-mir-129-5p
Nearest miRNA
hsa-mir-1180/Upstream/563297; hsa-mir-10226/Downstream/7385978;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/39370, chr17-CpG: 84/Downstream/69431
Upstream sequence
aaatctaatagcccaatctttttttttttaattggagatggagtctcactgtgttgcccagtctggtcttgagctcctgggctcaagcgatcccccaact
Downstream sequence
ggctcactgcaaccttcacctcctgggttcaggcaattctcctgcctcagcctcccaagtagccgggatcacaggtgccggccaccatgcctggctaagt
Target sequence
tttttttttgagcctgagttttgctctttttgcccagaccagagtgcagtggtgcgatctc
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.