Basic Information
VIS ID
TVIS10017192
Fusion event
HBV-chr11 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
2660
End
2775
Integrated sequence
AGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATA
Host Sequence
Chromosome
chr11
Cytoband
q13.5
Reference genome
GRCh37/hg19
Start
76306304/76595260 (Hg38)
End
76306428/76595384 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA11H
Nearest miRNA
hsa-mir-10392/Upstream/1260074; hsa-let-7a-2/Downstream/2806638;
Nearest TSS
ENST00000527297/Upstream/49312; ENST00000447519/Downstream/31450;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/149477, chr11-CpG: 92/Downstream/75021
Upstream sequence
ATGTTAAGTCTATCCCTCAGAGTGGGGGGACTTAACCTCTCTTATTGGTTTCAAGTTCTTGTTCCTCCTCTGTCATTCTCCATCTTCCTCTCCAAAGACA
Downstream sequence
agtgtggccattcctcaaagacctagaagcagaaataccacttgacgcagcagtcccattactgcgtatatacgcaaaggaatatgaatcattctattat
Target sequence
cacagcagtcagaatggctaattaaaaagtcaaaaaacaacagatactggcgaggttgtggagataaaggaacacatttacactgttggtgggaatgtaagttagttcaaccattgcagaagac
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate