Basic Information
VIS ID
TVIS10017193
Fusion event
HBV-chr11 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1853
End
1970
Integrated sequence
ATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTC
Host Sequence
Chromosome
chr11
Cytoband
q13.5
Reference genome
GRCh37/hg19
Start
76306181/76595137 (Hg38)
End
76306304/76595260 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA11H
Nearest miRNA
hsa-mir-10392/Upstream/1259951; hsa-let-7a-2/Downstream/2806762;
Nearest TSS
ENST00000527297/Upstream/49189; ENST00000447519/Downstream/31574;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/149354, chr11-CpG: 92/Downstream/75145
Upstream sequence
TCTTAGGGGGAAAAGTGGGTACATCATCATTTTGTAGGGCAATAAAGTTGGGAAAATCATTTTAAAAACCAGTTaacatttatataccacagttcctgtg
Downstream sequence
cacagcagtcagaatggctaattaaaaagtcaaaaaacaacagatactggcgaggttgtggagataaaggaacacatttacactgttggtgggaatgtaa
Target sequence
aaaggacatgaacagacacttctcaaaagaagacatacatgtagccaacaaacatatgaaaaaaatctcaacatcactgatcatcagagaaatgcaaatcaaaaccacaatgagataccatct
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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