Basic Information
VIS ID
TVIS10017196
Fusion event
HBV-chr8 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1954
End
2069
Integrated sequence
TTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGG
Host Sequence
Chromosome
chr8
Cytoband
q24.22
Reference genome
GRCh37/hg19
Start
135130538/134118295 (Hg38)
End
135130662/134118419 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1204/Upstream/1071714; hsa-mir-10400/Downstream/682101;
Nearest TSS
ENST00000518652/Upstream/231799; ENST00000505776/Downstream/202028;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/545579, chr8-CpG: 201/Downstream/345556
Upstream sequence
TTACTCTTTTGGGATGGAGTGAAAACCAGCAGCCTAAAACACAAAGGGGACAGCTGGAGAGAGGGAACTGTCAGCGTGTGAGAAGAAGCTATGACTCACC
Downstream sequence
aggaacgtagtatggaattactcaaaaaaattatttacttctatcccagggatccacaagcaatacccatgggtaaaatctgatcctcagtttttataaa
Target sequence
ttatagaagttggatgggtttcagacacagccaatggattattgcaaacaaaacagagttgactccaaaattgctatagctattccagctgtagtcattttactggatcaaataaacacagctt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate