Basic Information
VIS ID
TVIS10017203
Fusion event
HBV-chr2 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2055
End
2165
Integrated sequence
CATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTAT
Host Sequence
Chromosome
chr2
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
147479237/146721669 (Hg38)
End
147479360/146721792 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA2S ; FRA2K
Nearest miRNA
hsa-mir-128-1/Upstream/6134984; hsa-mir-10b/Downstream/2608486;
Nearest TSS
ENST00000437798/Upstream/806579; ENST00000450667/Downstream/115957;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/133858, chr2-CpG: 79/Downstream/1121919
Upstream sequence
AAGCTCTTAGGCCTCGGCCTTTAGGGGCTTGTTAGGCTCTGGCCCTCAGGGATCTCTGACTTCTCCCAGAGACTTCTAGGACAGAGGCTGAGAAAATATG
Downstream sequence
atactatactccagcaaaaggggacatgggtcacagaggtttccagctggcaaagcaacactctaaggaccctgtgacaCTATCCTGCAAGGAAGATGAG
Target sequence
cacatgcctgtcactgctccgcacctggcttgcccttggcaggcatgagattcgggctggtaatgtgagccgagtgcaacctgccaggccaagtgggtggaatgagcccagcaggcacaagta
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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