KCNS3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017207
Fusion event
HBV-KCNS3 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2965
End
3078
Integrated sequence
CACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTT
Host Sequence
Chromosome
chr2
Cytoband
p24.2
Reference genome
GRCh37/hg19
Start
18099920/17918653 (Hg38)
End
18100043/17918776 (Hg38)
Location type
Intron
Fragile sites / regions
FRA2C
Target gene
KCNS3
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-192-5p
Nearest miRNA
hsa-mir-3125/Upstream/5181209; hsa-mir-10b/Downstream/1429653;
Nearest TSS
ENST00000437798/Upstream/39270; ENST00000431697/Downstream/629428;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/39000, chr2-CpG: 69/Downstream/641426
Upstream sequence
aggccaataaagcttagatttgcccttttgaggttattttctagagcttgtaggcatgcttttttaattcttttttttctttctacccctatctttttct
Downstream sequence
AACATCATAATGCCTTGTGATATGTGCTAAAATCAAGGTGTACACAAATGGGCTATGGGAGAGGGTAGAGAAGAGAGAACCATTAATTTGGCCTGGGCCC
Target sequence
GGGCAGCACTTAGCATAAGGGGCTATAGCTGTAAGAGGATAATACATGGTCCCTTCCACAGCGAAGCTTGGAGTCTAGAGTGAGCAACAATCAGACTTGTGGGGAATAAGGAGAATTGTAGAT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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