CTDSPL _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017208
Fusion event
HBV-CTDSPL integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2081
End
2198
Integrated sequence
TTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAA
Host Sequence
Chromosome
chr3
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
37934556/37893065 (Hg38)
End
37934682/37893191 (Hg38)
Location type
Intron
Target gene
CTDSPL
miRNAs that regulate target gene
hsa-mir-100-5p ; hsa-mir-124-3p ; hsa-mir-183-5p ; hsa-mir-18a-5p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-651-3p ; hsa-mir-4524a-5p ; hsa-mir-4524b-5p ; hsa-mir-6830-5p ; hsa-mir-6838-5p ; hsa-mir-99a-5p ; hsa-mir-770-5p ; hsa-mir-500a-3p ; hsa-mir-767-5p ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-186-3p ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-4258 ; hsa-mir-6753-5p ; hsa-mir-1911-3p ; hsa-mir-8485 ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-12127/Upstream/2148506; hsa-let-7g/Downstream/76213;
Nearest TSS
ENST00000440867/Upstream/30887; ENST00000416688/Downstream/51523;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/30517, chr3-CpG: 29/Downstream/101019
Nearest cancer related gene
CTDSPL(TSG, No orient, 0)
Upstream sequence
TCACCTTTCTGGTGAGGATGCATCTTATATCAGAAGAAGATGGAAGTACATTTCTAGGGAGGTATTCACAGGATTTAATAACACTTATTGGTTTGGAAAT
Downstream sequence
TGGATGTCAGAGGCTAGTTAATAACTGTGTTTGGCAATCAGCTTGGGATGTTAACAGCTTCTAGGTTTAAGGAAGGCCAGAAGAATAGTATGAAGGAAAT
Target sequence
GTTCCATTGTGCAGGCATGTGCCACCAACCGTGGAGTGGACTTCCTGCTGCAGGACACAGCTGACCTTTGGAGAGTCACTGTCTGAGTGAGGCTGCCCTTTAGCAGGACAGAACACAGCTGTTGTT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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