CTDSPL _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017209
Fusion event
HBV-CTDSPL integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1713
End
1825
Integrated sequence
AGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT
Host Sequence
Chromosome
chr3
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
37934714/37893223 (Hg38)
End
37934823/37893332 (Hg38)
Location type
Intron
Target gene
CTDSPL
miRNAs that regulate target gene
hsa-mir-100-5p ; hsa-mir-124-3p ; hsa-mir-183-5p ; hsa-mir-18a-5p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-651-3p ; hsa-mir-4524a-5p ; hsa-mir-4524b-5p ; hsa-mir-6830-5p ; hsa-mir-6838-5p ; hsa-mir-99a-5p ; hsa-mir-770-5p ; hsa-mir-500a-3p ; hsa-mir-767-5p ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-186-3p ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-4258 ; hsa-mir-6753-5p ; hsa-mir-1911-3p ; hsa-mir-8485 ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-12127/Upstream/2148664; hsa-let-7g/Downstream/76072;
Nearest TSS
ENST00000440867/Upstream/31045; ENST00000416688/Downstream/51382;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/30675, chr3-CpG: 29/Downstream/100878
Nearest cancer related gene
CTDSPL(TSG, No orient, 0)
Upstream sequence
ATAGGTGGTTATAATCCTGCCGGTGTAACAAACAATGTTTGAGAGCAAAAAACAGTAAGAGGAGCCAGAGCAAGCATAAGATCAACAACTACATTACTAT
Downstream sequence
CAAAAATTAACACTTCACAGCAGCTTTAAAAAGTATTAAGAGAACTCATAAAAGTCAGAGCAGATGTGCTGGAGATCACACTTCCAGAGCTCTCTGGGGA
Target sequence
GGCAATCAGCTTGGGATGTTAACAGCTTCTAGGTTTAAGGAAGGCCAGAAGAATAGTATGAAGGAAATCTTTGTGTTACCAACAGGTTCTTTGGTAATCTTTCTTTGAA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate