Basic Information
VIS ID
TVIS10017216
Fusion event
HBV-chr7 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1812
End
1926
Integrated sequence
ACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr7
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
108513085/108873028 (Hg38)
End
108513208/108873151 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10525/Upstream/6401497; hsa-mir-10399/Downstream/5780194;
Nearest TSS
ENST00000635602/Upstream/274653; ENST00000413406/Downstream/11436;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/302566, chr7-CpG: 68/Downstream/2688872
Upstream sequence
GAGACTTTGAATGCTGTGGGAATGGCTGTCACCAGCACGTGGCTTGATCAGGGCTTTCTTCTCCTTGCAGTTGTGGCCCCATCAAAGTGAAAACTGAACC
Downstream sequence
GAAATCCATAGGCTTATTCTTGCAACACTCTCCTTCCTTCAAATAAAAGAGAAGAAATATTGCAATTCTTGTGAGTGGATGTGAAAACTTACATTGCACA
Target sequence
GATTATGTTGGAAACAATGTACTTAAGCCAAAGCATTAGAATGTGACTTGTTTTCCAGAATTCTCAGAATTGTTGGACTGTAGAGAGGCTTTGGGACAGTCAATTAAATGTTAAGATTTACCA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate