Basic Information
VIS ID
TVIS10017217
Fusion event
HBV-chr7 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1996
End
2110
Integrated sequence
ATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTAC
Host Sequence
Chromosome
chr7
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
70268168/70803182 (Hg38)
End
70268284/70803298 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA7J
Nearest miRNA
hsa-mir-1183/Upstream/3688785; hsa-mir-10399/Downstream/504374;
Nearest TSS
ENST00000635602/Upstream/16261; ENST00000447516/Downstream/328871;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/12182, chr7-CpG: 237/Downstream/327944
Upstream sequence
CCATGCATTGTTCAtttctttttctttttttttgagagggagtctcgccgtgtcacccaggctggagtgcagtggcacaattttggcccTTCCCAAAGTC
Downstream sequence
ggacaatggattgagcccaggagttcaagactgctgcagtgcactataattgccagaacccatctctcaaaaacaaacaaacaaacacaatataacacct
Target sequence
gcatcacgctacctgattccagaacatactacagtgctacagtaaccaaaacagcatggtactgccaggcaccatggcacccacctgtagtcccatttacttgggaagctgaggag
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate