AUTS2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017218
Fusion event
HBV-AUTS2 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
790
End
904
Integrated sequence
TTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACTCTCTAAATTTTATGGGTTATGTCATTGGATGTTATGGG
Host Sequence
Chromosome
chr7
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
70233375/70768389 (Hg38)
End
70233493/70768507 (Hg38)
Location type
Intron
Fragile sites / regions
FRA7J
Target gene
AUTS2
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-222-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1183/Upstream/3653992; hsa-mir-10399/Downstream/539165;
Nearest TSS
ENST00000635602/Upstream/2044; ENST00000646136/Downstream/2940;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/72688, chr7-CpG: 92/Downstream/21401
Upstream sequence
CTACACAATCTAGCTGAAAGTTCTCACATGCAATCATATCATTGCATTTGCTTTTCTAGGCATTTCCCTGGAAATGGCAGCTGTGACAGTAAAGGAAGAA
Downstream sequence
TTCATTTGCTCTAGACTAAATGTAGAACCTTCTTCCACATGGCTGGTATTGTTCTGTTGAGTTTGTTACAATAGAAAGTAAAAATATCACTTAATTAAAA
Target sequence
TTTCAGTCGTCAGTTGAAATGCCACTAACACAGAAGTTCTGGAATGCAACCTGAATTATTTCCTCTTAAATAGAAAGTCCCTTGTCTTTTTGACTCATGACTCTTCAACAAGTAGATT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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