FGF8 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017219
Fusion event
HBV-FGF8 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1712
End
1826
Integrated sequence
AAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT
Host Sequence
Chromosome
chr10
Cytoband
q24.32
Reference genome
GRCh37/hg19
Start
103536382/101776625 (Hg38)
End
103536505/101776748 (Hg38)
Location type
Promoter
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
FGF8
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-503-5p
Nearest miRNA
hsa-mir-107/Upstream/175128; hsa-mir-1307/Downstream/659764;
Nearest TSS
ENST00000439456/Upstream/528; ENST00000412353/Downstream/3621;
Nearest CpG islands
chr10-CpG: 124/Target, None/Upstream, None/Downstream
Nearest cancer related gene
FGF8(OG, No orient, 0)
Upstream sequence
GTCACGGCCAGGCAATCTGTCACCTTTGGGTCTCACTGGGTCCACAGGGACCTGGGGCACTGGAGAGGAGCAGAAGGGGGAAGAGTAAAGAGCCCGCACC
Downstream sequence
GTCTCTCCAGTCTCCTTCACTCTCCCGAGGAGGCCCTGGGAGCCAGAAATGCCTCCCCCTCCCCCCATCCCATTATCACTATCACCCCTTCCCCTGTGCC
Target sequence
CCGGGCCCCTGGGAGCGGCCGCTAACCATGCAGCGAATGGCTGCGCACCCGGCCCTCGCGCAGTGCGTGCCGGTGCCACCCGGACCCCGCTCCCCTGTTTCGGCCGCGTGCCCCGTCCTGTCG
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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