FGF8 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017220
Fusion event
HBV-FGF8 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1848
End
1961
Integrated sequence
TGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCT
Host Sequence
Chromosome
chr10
Cytoband
q24.32
Reference genome
GRCh37/hg19
Start
103536506/101776749 (Hg38)
End
103536625/101776868 (Hg38)
Location type
Promoter
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
FGF8
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-503-5p
Nearest miRNA
hsa-mir-107/Upstream/175252; hsa-mir-1307/Downstream/659644;
Nearest TSS
ENST00000439456/Upstream/652; ENST00000412353/Downstream/3501;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/1, chr10-CpG: 97/Downstream/2213
Nearest cancer related gene
FGF8(OG, No orient, 0)
Upstream sequence
AGAACCAGCAGAAGCCCCGAGGGCCTGGACAGACACATGTCCACAGCCAGGCCCAGCAGAAGACAATGTGGAAGAAGCAAGGCAGCCCACCGTGTCTTTT
Downstream sequence
cacacacacacacacacacacacacTAGCCTGAAGCTTGAGGAGCACCCCGAGCCACCTGTGTGGAAGAGAGAGTCCGGAGGTCCCTGGCAGGACCCACT
Target sequence
TCTCTCCAGTCTCCTTCACTCTCCCGAGGAGGCCCTGGGAGCCAGAAATGCCTCCCCCTCCCCCCATCCCATTATCACTATCACCCCTTCCCCTGTGCCCCTCACcacacacacacaca
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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