Basic Information
VIS ID
TVIS10017221
Fusion event
HBV-ZNF8-ERVK3-1 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2730
End
2832
Integrated sequence
CTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGG
Host Sequence
Chromosome
chr19
Cytoband
q13.43
Reference genome
GRCh37/hg19
Start
58810806/58299440 (Hg38)
End
58810913/58299547 (Hg38)
Location type
Intron
Fragile sites / regions
FRA19A
Target gene
ZNF8-ERVK3-1
Nearest miRNA
hsa-let-7e/Upstream/2911198; hsa-mir-10394/Downstream/35141;
Nearest TSS
ENST00000633603/Upstream/20474; ENST00000434052/Downstream/5772;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/19834, chr19-CpG: 44/Downstream/5614
Upstream sequence
AGCATTGCGGGGAACCCTCAGAACCTGCCTTTCTGTGATCCCCCACCTTCCTTTGTTCCTCCCCAGACCTGGCCCTTCTCTGTGCTAGTTCCCTGTCCCT
Downstream sequence
tcacgaggtcaggagatcgagaccagcctggctaacacggtgaaaccctgtctctactaaaaatacaaaaaattagcctggcgtggtggcgggcgcctgt
Target sequence
GAATGGTTGAGCATTGGAACGCATTAGCATCAGAACTTCCCGTGTCAggccaggcgcggtggctcacgcctgtaatcccagcactttcggaggccgagatgggcaga
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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