Basic Information
VIS ID
TVIS10017222
Fusion event
HBV-ZNF8-ERVK3-1 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
524
End
628
Integrated sequence
CTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTT
Host Sequence
Chromosome
chr19
Cytoband
q13.43
Reference genome
GRCh37/hg19
Start
58811230/58299864 (Hg38)
End
58811339/58299973 (Hg38)
Location type
Intron
Fragile sites / regions
FRA19A
Target gene
ZNF8-ERVK3-1
Nearest miRNA
hsa-let-7e/Upstream/2911622; hsa-mir-10394/Downstream/34715;
Nearest TSS
ENST00000633603/Upstream/20898; ENST00000434052/Downstream/5346;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/20258, chr19-CpG: 44/Downstream/5188
Upstream sequence
AGAGACAGGCAGGGTATACAGAAGGGCTATGggcacactgcagctcaaatcccagctctctgcccactagctgtgtggccctgggcaagtcacctgactt
Downstream sequence
TTGCCGTGTCAGCTCTCACTTTTCACAGCAACTCTGGCCTCCTACCTTGGACTGCGCCACTTCTGTCTCCTTAGATAACCTCCATTCGCATAGCTAAATG
Target sequence
GATGCCAGAGCCAGAGCTTTGTGGTTCATCTCTAGAGGTTCAACAGGACCCTGTGGATGGCCCAAGTTCGTTTCTCTGCACTTACCTCTTCGGGGTTGTCCTCAAAACG
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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