DRG2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017223
Fusion event
HBV-DRG2 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
2097
End
2153
Integrated sequence
ATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTA
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
17987605/18084291 (Hg38)
End
17987729/18084415 (Hg38)
Location type
Promoter
Target gene
DRG2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-let-7b-5p ; hsa-mir-616-5p ; hsa-mir-193b-3p
Nearest miRNA
hsa-mir-1253/Upstream/270360; hsa-mir-10226/Downstream/256399;
Nearest TSS
ENST00000595228/Upstream/18202; ENST00000473213/Downstream/3471;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/44110, chr17-CpG: 44/Downstream/3351
Upstream sequence
CGCAGACGCAGCTCCTTGTAAACTTCAGCCTGGGCCAGGAAGAGGGGCTCCGTGGGGTTGGGGGTGGGGCTTTCCGGGTGGTCGAAGAGCCTGGGGTCAG
Downstream sequence
gcagcctttaccttctgggctcacgtgatcctcttgcctcagccttctcagtaatcaggactacaggtacacaccaccacacccagcttggaatgtcttt
Target sequence
CCAAATTGTCCTCAGAATGTTTTCTATTTATTCAAAAtttttgtttatttatttaatttattttagagacagcatctcactctatggcccaggctggtgtgcagtggtgtgattatggctcact
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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