Fusion event
HBV-chr20 integration
Detection method
Capture-NGS platform
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
ACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCC
End
47181883/48565345 (Hg38)
Nearest miRNA
hsa-mir-103a-2/Upstream/1398167; hsa-mir-1-1/Downstream/1298514;
Upstream sequence
GTGGCTGTGCCTCTCTCGTGAGGTTTTCCAAAGAGTCCTGTTCTCTTTGGCTTTGACGTTTTAAAGGGTTAAAATAGCaacaacaacaaattctaattaa
Downstream sequence
ccgacactttggtatctgggaccatgctgaccctgacctgcctttctgagggttagccaattcttgataaagcatgcttttcaaatacaaaccaaccaac
Target sequence
gctccatcctacagccaaACATGTAAGGTGGATAAGGGAGAAGGCGTTACCTCCCTTATCGAGGCGAAAGGCTGTAACTAGGAGGAGGGtgcactaaccacgtgttttattttctgtatt
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.