GABRG3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017227
Fusion event
HBV-GABRG3 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1825
End
1931
Integrated sequence
TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGA
Host Sequence
Chromosome
chr15
Cytoband
q12
Reference genome
GRCh37/hg19
Start
27443402/27198255 (Hg38)
End
27443516/27198369 (Hg38)
Location type
Intron
Target gene
GABRG3
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-1268a/Upstream/1349430; hsa-mir-10393/Downstream/1228122;
Nearest TSS
ENST00000557528/Upstream/36936; ENST00000554786/Downstream/73172;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/226546, chr15-CpG: 40/Downstream/343203
Upstream sequence
AAAGTGTTACTGGATTTGTTGAATATTAATGACAGCTGAATATTAATCTATAAGAATTTCTAAACTAATGTCAGCAGAATTACCACTGTGTTAACTACAG
Downstream sequence
gtgtggccaaaaaacatatgaaaaaaagatcatcatcactggtcattagagaaatgcaaatcaaaaccacaatgtggtaccatctcaagccagttagaat
Target sequence
aaagggctaatatccagaatctacaaggaacttaaacaaatttacaagaaaaaaacaaccccatcaaaaagtgggcgaaggatatgaacagacatctttcaaaagaagacattt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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