Basic Information
VIS ID
TVIS10017229
Fusion event
HBV-chr4 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1662
End
1775
Integrated sequence
GACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACT
Host Sequence
Chromosome
chr4
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
32806306/32804684 (Hg38)
End
32806424/32804802 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA4D
Nearest miRNA
hsa-mir-12113/Upstream/3985016; hsa-mir-1243/Downstream/3621564;
Nearest TSS
ENST00000502981/Upstream/453646; ENST00000515263/Downstream/628708;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2081464, chr4-CpG: 100/Downstream/3439207
Upstream sequence
atttgattgcatgctattccattccattccgttccattcctttccacttgggttgattccattccattcaattccgttccgttctgtcccgttccgtgcc
Downstream sequence
atgtcctcctgattgacaaaaaagtagacatatttaattatagtatttaacttcaagtgacatagtggactcttcatgatgtaggacttgtggctgccat
Target sequence
gaagaccaattataaccagaatgaaaggacctcttttgggGGTCCtttatccttaatccactgcaccctagcctctccccctagcaaactgctgaaatgccactgttatgagtcacca
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate