Basic Information
VIS ID
TVIS10017230
Fusion event
HBV-chr4 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1818
End
1918
Integrated sequence
CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chr4
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
32806427/32804805 (Hg38)
End
32806536/32804914 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA4D
Nearest miRNA
hsa-mir-12113/Upstream/3985137; hsa-mir-1243/Downstream/3621452;
Nearest TSS
ENST00000502981/Upstream/453767; ENST00000515263/Downstream/628596;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2081585, chr4-CpG: 100/Downstream/3439095
Upstream sequence
tcttctaaacctaattatctttcaaaggctcaatctcctgataccagtatattgggagttagggctgtaacatataaatgggggagagggggacatacaa
Downstream sequence
tatgttggtgggtttcttcaactctggctcttacttcttagtgaacttcccaggttctttattctcctctgtccattctttacattgTTGATGTTCTTTT
Target sequence
tcctcctgattgacaaaaaagtagacatatttaattatagtatttaacttcaagtgacatagtggactcttcatgatgtaggacttgtggctgccatggcagaaagaac
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate