Basic Information
VIS ID
TVIS10017235
Fusion event
HBV-chr7 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1160
End
1275
Integrated sequence
CAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGC
Host Sequence
Chromosome
chr7
Cytoband
q31.32
Reference genome
GRCh37/hg19
Start
121925348/122285294 (Hg38)
End
121925468/122285414 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10525/Upstream/5264975; hsa-mir-10399/Downstream/4772674;
Nearest TSS
ENST00000635602/Upstream/68947; ENST00000437317/Downstream/18244;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/140685, chr7-CpG: 53/Downstream/14538
Upstream sequence
CCACCCTCTTCCCTCCAGTCACTTTCCCGGTTCTTCTCCCACTGACCCAGGTAAATCACAAGAGGGATAAAGCCCCAGCGAATGGCAAACTGGCTCCCCT
Downstream sequence
tatttctaaagtgataaataggtaactttctcattaggaggttatagtgttgaggatgacctgaatattcaccatccttgctattctaacaattttaatt
Target sequence
aattcttgtacatacctatagaaacctgtgttccaaaaactctttaaagtatgtagctaatggaggaatatctagatgatagaaaatgtgtacaggcaaacttactagacaatgacaaaa
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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