Basic Information
VIS ID
TVIS10017236
Fusion event
HBV-LOC105370062 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
956
End
1071
Integrated sequence
CTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATG
Host Sequence
Chromosome
chr12
Cytoband
q24.32
Reference genome
GRCh37/hg19
Start
127650866/127166321 (Hg38)
End
127650974/127166429 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
LOC105370062
Nearest miRNA
hsa-let-7i/Upstream/2250662; hsa-mir-3612/Downstream/1127663;
Nearest TSS
ENST00000382841/Upstream/19172; ENST00000535247/Downstream/117854;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/19667, chr12-CpG: 32/Downstream/114302
Upstream sequence
ATTACCTGAGCATGAAAATACAGAAGGAAAACATTAAGACCATTTTAAAGGAGTTTGGAAATTTAGCATAACATAGGCAGGAAATAGGAATGAATCATCA
Downstream sequence
gctcctcagccaaTGGGATCTGATTTTTTAAGCAGTCACAACACTAGACTTTTAATTGAGAAAGCTCTGTAAGCAATTAAAAGCCGCTGTTGTTTTAAAC
Target sequence
cgaggccaaccgaggcgccgcggggctgccgtatcgttccgcctgggcgggattctgacttaagaggcgttcagtcataatcccacagatggtagcttcgccccattg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate