Basic Information
VIS ID
TVIS10017238
Fusion event
HBV-chr16 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1703
End
1818
Integrated sequence
CATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC
Host Sequence
Chromosome
chr16
Cytoband
q21
Reference genome
GRCh37/hg19
Start
62879334/62845430 (Hg38)
End
62879457/62845553 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/5073078; hsa-mir-11401/Downstream/4356768;
Nearest TSS
ENST00000527434/Upstream/249058; ENST00000561595/Downstream/523291;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/808700, chr16-CpG: 19/Downstream/2105225
Nearby gene
LOC102723560(-9728) ;
Upstream sequence
gtgcagtggcttgcaatcttggctcactgcaagctccgcctcccgggttcacgccattctcctgcctcagcctcccgagtagctgggactgcaggcaccc
Downstream sequence
tgtgtgtgtttagcagagacggggtttcaccttgttagccaggatggtctcgatctcctgacctcgagatccacccgcttcggcctcccaaactgctggg
Target sequence
tggctcactgcaagctccgcctcccgggttcacgccattctcctgcctcagcctcccgagtagctgggactgcaggcacccgccaccacgcctggctaattcttttgtgtgtgtgtgtgtgtg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate