Basic Information
VIS ID
TVIS10017239
Fusion event
HBV-chr16 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1673
End
1789
Integrated sequence
TCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGC
Host Sequence
Chromosome
chr16
Cytoband
q21
Reference genome
GRCh37/hg19
Start
62879485/62845581 (Hg38)
End
62879609/62845705 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/5073229; hsa-mir-11401/Downstream/4356616;
Nearest TSS
ENST00000527434/Upstream/249209; ENST00000561595/Downstream/523139;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/808851, chr16-CpG: 19/Downstream/2105073
Nearby gene
LOC102723560(-9879) ;
Upstream sequence
tctgaAAACGTAGTTCCTCtttttttttttttttttttttttttttttgagacagagtcttgctctgtggcccaggctgcagtgcagtggcttgcaatct
Downstream sequence
AGGTGAGGTTTGCTTAACCTCTATCACCTTTCTCTAatagtacattatcaatatcaggacattaatactggcaaaatactaagaactagattacaaaacg
Target sequence
accttgttagccaggatggtctcgatctcctgacctcgagatccacccgcttcggcctcccaaactgctgggattacaggcgtgagccaccgcctccggcTTCCTTTTCTTAATGACTATGGTG
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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