Basic Information
VIS ID
TVIS10017240
Fusion event
HBV-chr2 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1713
End
1825
Integrated sequence
AGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT
Host Sequence
Chromosome
chr2
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
133036670/132279097 (Hg38)
End
133036767/132279194 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1285-2/Upstream/22017; hsa-mir-10b/Downstream/154517;
Nearest TSS
ENST00000437798/Upstream/21128; ENST00000622084/Downstream/15183;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/20930, chr2-CpG: 79/Downstream/73549
Nearby gene
LOC105373622(-2198) ; RNA28SP(+337) ;
Upstream sequence
TATCCTTTAGAAAAGTGAATAATAATTTTTGCTGCAAAGTGGTATACCAGCACATTTGTCTATAAATTTACATTCTTGGATATTAGCAAAATTGCAAGGG
Downstream sequence
ataggaagaaccaacattacaggatcaaaaaacatccctatgaatgcttggccgcaacgaaccagttatcccctgtggtaacttctgatacctcctgctt
Target sequence
gggtaaaactaacctgtctcactacgatctaaatccagctcacatgccctattagtgggtgaacaatccaatgcttggtgaattctacttcacaatg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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