Basic Information
VIS ID
TVIS10017242
Fusion event
HBV-chr3 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1822
End
1932
Integrated sequence
TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAG
Host Sequence
Chromosome
chr3
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
80259073/80209923 (Hg38)
End
80259190/80210040 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/701954; hsa-mir-12124/Downstream/5175670;
Nearest TSS
ENST00000440867/Upstream/442108; ENST00000473938/Downstream/554857;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/443173, chr3-CpG: 75/Downstream/1551124
Nearby gene
HNRNPA3P8(+6338) ;
Upstream sequence
gggctctgaggccttggccctcctctgggcctcattttcttcatctgtaaaaaaggttgcagaagtctttagccccggttgatatttgagcaacctcatg
Downstream sequence
ttctagatgtcacatgttttcttggctcatagccctcttccaacttcatagccctcttcttcttcatagccagtaataataggtaaagtccttctcacat
Target sequence
tgggttggttccaagtctttgctattgtgaatagACTGtggcaaaatttagttccctgtagttgtaggactaaggcactgaatttctggctagctggaagctgagagattttctagc
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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