Basic Information
VIS ID
TVIS10017245
Fusion event
HBV-chr12 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1695
End
1785
Integrated sequence
CCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGT
Host Sequence
Chromosome
chr12
Cytoband
p13.33
Reference genome
GRCh37/hg19
Start
820335/711169 (Hg38)
End
820434/711268 (Hg38)
Location type
Intronic
Target gene
LINC02455 ; LOC101929432
Nearest miRNA
hsa-let-7i/Downstream/949047;
Nearest TSS
ENST00000382841/Upstream/27042; ENST00000447667/Downstream/41325;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/67680, chr12-CpG: 197/Downstream/41008
Upstream sequence
gctggttgtttcctttgctgtgcagcagcttcttactttgatgtggtctcacttgtttatttttgtttttatggtctatgcttttcatgttatgctgcct
Downstream sequence
gttggaatattacaaatgtctcctagctattttgaaatacacaataaagtattattaactagaatccccctactgtactattgCATTATTTCTTATTATA
Target sequence
aaactcctagctacaagtgatcctctcacctcagcctacaaaagtgctggaattataggcatgagccactgcgcccaacttcattaatcttttctttat
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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