Basic Information
VIS ID
TVIS10017246
Fusion event
HBV-LINC02498 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1735
End
1825
Integrated sequence
GAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
10777081/10775457 (Hg38)
End
10777172/10775548 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
LINC02498
Nearest miRNA
hsa-mir-3138/Upstream/696765; hsa-mir-12113/Downstream/593279;
Nearest TSS
ENST00000502981/Upstream/37885; ENST00000515343/Downstream/653049;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/313392, chr4-CpG: 74/Downstream/593122
Upstream sequence
ACCTGGGATgacttccagtaaaagatggcaggcttgacaaatacataaatttccttcctgaaatcctaataagaatacaggaattaggccgggtgcggtg
Downstream sequence
ccaccccacaacagtccccagagtgtgatgttccccttcctgtgtccatgtgatctcattgttcaattcccacctatgagtgagaatatgtggtgttggg
Target sequence
atgtatacatgtgccatgctggtgcactgcacccactaactcgtcatctagcattaggtatatctcccgatgctatccctccccactcccc
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate